Optimal Tmax Threshold for Predicting Penumbral Tissue in Acute Stroke
نویسندگان
چکیده
منابع مشابه
Optimal Tmax threshold for predicting penumbral tissue in acute stroke.
BACKGROUND AND PURPOSE We sought to assess whether the volume of the ischemic penumbra can be estimated more accurately by altering the threshold selected for defining perfusion-weighting imaging (PWI) lesions. METHODS DEFUSE is a multicenter study in which consecutive acute stroke patients were treated with intravenous tissue-type plasminogen activator 3 to 6 hours after stroke onset. Magnet...
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The goal of acute stroke treatment with intravenous thrombolysis or endovascular recanalization techniques is to rescue the penumbral tissue. Therefore, knowing the factors that influence the loss of penumbral tissue is of major interest. In this study we aimed to identify factors that determine the evolution of the penumbra in patients with proximal (M1 or M2) middle cerebral artery occlusion....
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BACKGROUND AND PURPOSE Identification of salvageable penumbra tissue by dynamic susceptibility contrast magnetic resonance imaging is a valuable tool for acute stroke patient stratification for treatment. However, prior studies have not attempted to combine the different perfusion maps into a predictive model. In this study, we established a multiparametric perfusion imaging model and cross-val...
متن کاملMaps of time to maximum and time to peak for mismatch definition in clinical stroke studies validated with positron emission tomography.
BACKGROUND AND PURPOSE Perfusion-weighted imaging-derived maps of time-to-maximum (Tmax) are increasingly used to identify the tissue at risk in clinical stroke studies (eg, DEFUSE and EPITHET). Using quantitative positron emission tomography (PET), we evaluated Tmax to define the penumbral flow threshold in stroke patients and compared its performance to nondeconvolved time-to-peak (TTP) maps....
متن کاملPredicting outcome in acute stroke.
The natural history of acute stroke is well defined. Predicting outcome in individuals, however, remains difficult, because prognostic studies examining associations between clinical signs or syndromes and outcome differ in patient selection, timing and choice of neurological assessments and outcome measures. Accuracy has been disappointing. Osler in 1892 stated that the 'course of the disease ...
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ژورنال
عنوان ژورنال: Stroke
سال: 2009
ISSN: 0039-2499,1524-4628
DOI: 10.1161/strokeaha.108.526954